Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Peripheral Blood CD8(+) T Cells CCR5 Expression and Its Delta 32 Mutation in Iranian Patients with Occult Hepatitis B Infections

(2010) Peripheral Blood CD8(+) T Cells CCR5 Expression and Its Delta 32 Mutation in Iranian Patients with Occult Hepatitis B Infections. Labmedicine. pp. 226-230. ISSN 0007-5027

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Abstract

Background: The main purpose of this study was to investigate the expression of the CCR5 and the Delta 32 mutation in its gene on the CD8(+) T cells in blood donors suffering from an occult hepatitis B infection (OBI). Methodology: The studied population included 57 OBI HBsAg/anti-HBc(+) patients with positive HBV-DNA. Flow cytometric analysis and Gap-PCR was performed to examine the expression of CCR5 on CD8(+) T cells and CCR5-Delta 32 mutations, respectively. Results: Flow cytometric analysis indicated that the number of cells which simultaneously co-express CD8 and CCR5 are decreased significantly in patients; no OBI patients had CCR5-432 mutations. Conclusions: Based on the results of this study, it can be concluded that the expression of CCR5 on CD8(+) T cells is defected in OBI patients. This may be directly related to the CCR5 gene defect (primary abnormality) or CCR5 expressing inducers (secondary abnormality), such as cytokines.

Item Type: Article
Keywords: Occult hepatitis B infection CCR5 CD8(+) T cells HBsAg HBV-DNA Delta 32 mutation hepatocellular-carcinoma immune-responses c virus liver polymorphisms involvement lymphocytes Medical Laboratory Technology
Page Range: pp. 226-230
Journal or Publication Title: Labmedicine
Journal Index: ISI
Volume: 41
Number: 4
Identification Number: https://doi.org/10.1309/lmvukwr0x0ebqr01
ISSN: 0007-5027
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4859

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