Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

THE INTRACEREBROVENTRICULAR (ICV) ADMINISTRATION OF W-7, A CALMODULIN INHIBITOR, ATTENUATES THE DEVELOPMENT OF MORPHINE TOLERANCE IN RATS

(2010) THE INTRACEREBROVENTRICULAR (ICV) ADMINISTRATION OF W-7, A CALMODULIN INHIBITOR, ATTENUATES THE DEVELOPMENT OF MORPHINE TOLERANCE IN RATS. Pakistan Journal of Pharmaceutical Sciences. pp. 170-174. ISSN 1011-601X

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Abstract

The present study was performed to determine the effect of intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the development of tolerance to antinociceptive effect morphine administration. This study was carried out on male wistar rats, weighing 200-250 g. Morphine was administered daily (15 mg/kg for 8 days) The threshold to thermal nociceptive stimuli was measured by tail-flick test. W-7 (0 25, 0.5 and 1 mu mol/rat) was injected through ICV Maximal possible effect percentage (MPE ) was considered as analgesia index Our result showed that chronic morphine exposure induced tolerance to its antinociceptive effect and administration of W-7 (0.5 and 1 mu mol/rat) decreased the development of tolerance to it. In conclusion these data showed that chronic injection of W-7 inhibited the development of morphine tolerance which indicates that calmodulin and its dependent pathways may play a role in the morphine tolerance processes

Item Type: Article
Keywords: Calmodulin inhibitor (W-7) morphine tolerance rat mu-opioid receptor protein-kinase-ii molecular-mechanisms modulation expression calcium phosphorylation desensitization translocation stimulation Pharmacology & Pharmacy
Page Range: pp. 170-174
Journal or Publication Title: Pakistan Journal of Pharmaceutical Sciences
Journal Index: ISI
Volume: 23
Number: 2
ISSN: 1011-601X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4860

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