Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Nephropathic complication of type-2 diabetes is following pattern of autoimmune diseases?

(2010) Nephropathic complication of type-2 diabetes is following pattern of autoimmune diseases? Diabetes Research and Clinical Practice. pp. 33-37. ISSN 0168-8227

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Abstract

The impact of several environmental and genetic factors on diabetes and its complications is well documented. The present study was aimed to examine the serum levels of IL-17A and IFN-gamma as antagonistic cytokines in nephropathic and non-nephropathic type-2 diabetic patients. in this experimental study, serum samples were obtained from 180 type-2 diabetic patients, 100 nephropathic type-2 diabetic patients and 100 healthy controls. Serum levels of IL-17A and IFN-gamma was detected by ELISA. Results of this study showed that the serum level of IFN-gamma was higher in both diabetic patients (nephropathic and non-nephropathic) in comparison to the controls. In terms of IL-17A, while non-nephropathic type-2 diabetic patients showed an increased serum level of it, the other patients group had a lower serum level. Based on these findings, it can be concluded that the lower serum level of IL-17A is possibly associated with nephropathic complications of type-2 diabetes. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Item Type: Article
Keywords: IFN-gamma IL-17A Diabetes Nephropathy necrosis-factor-alpha interferon-gamma tnf-alpha t-cells serum cytokines interleukin-17 induction mellitus profile Endocrinology & Metabolism
Page Range: pp. 33-37
Journal or Publication Title: Diabetes Research and Clinical Practice
Journal Index: ISI
Volume: 87
Number: 1
Identification Number: https://doi.org/10.1016/j.diabres.2009.09.027
ISSN: 0168-8227
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4867

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