Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

No Association Between CCR5-Delta 32 Mutation and Multiple Sclerosis in Patients of Southeastern Iran

(2010) No Association Between CCR5-Delta 32 Mutation and Multiple Sclerosis in Patients of Southeastern Iran. Labmedicine. pp. 31-33. ISSN 0007-5027

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Abstract

Background: Multiple sclerosis (MS) is considered a complicated autoimmune disorder. Evidence is in favor of involvement of chemokines and their receptors in autoimmune diseases. Hence, this project aimed to analyze the known CCR5-Delta 32 mutation in MS patients. Methods: In this experimental study, blood samples were collected from 100 MS patients and 300 healthy controls in EDTA pre-coated tubes. DNA was extracted and DNA samples were analyzed for CCR5-Delta 32 mutation by Gap-PCR in patients and controls. Demographic data were also collected by questionnaire. Results: Our findings showed that none of the MS patients displayed CCR5-Delta 32 mutation, while 2 healthy controls showed the heterozigotic form of this mutation Conclusions: Several studies analyzed the relation of this mutation with autoimmune diseases. Some studies failed, but some succeeded in finding an association between this mutation and autoimmune diseases. Based on the results of our study, it could be concluded that this mutation does not play a role in the etiology and pathogenesis of MS.

Item Type: Article
Keywords: ccr5 deletion mutation disease course polymorphism receptor expression model Medical Laboratory Technology
Page Range: pp. 31-33
Journal or Publication Title: Labmedicine
Journal Index: ISI
Volume: 41
Number: 1
Identification Number: https://doi.org/10.1309/lm9tu9id1cgzvlxl
ISSN: 0007-5027
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4871

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