Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats

(2009) URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats. Canadian Journal of Physiology and Pharmacology. pp. 432-439. ISSN 0008-4212

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Abstract

Diabetic rats display increased pain responses after injection of formalin into the paw or thermal stimulation of the tail, suggesting the presence of hyperalgesia. In this study, we investigated the efficacy of URB597 (0.1, 0.3, and 0.5 mg/kg, i.p.), an inhibitor of endocannabinoids metabolism, on 2 models of experimental hyperalgesia in streptozotocin (STZ)-induced diabetic rats. Animals were divided into control, URB597-treated control (0.1, 0.3, and 0.5 mg/kg), diabetic, and URB597-treated diabetic (0.1, 0.3, and 0.5 mg/kg) groups. Formalin and tail-flick tests were performed 4 and 8 weeks after the onset of hyperglycemia, respectively. Diabetes caused significant hyperalgesia during these tests. URB597 (0.3 and 0.5 mg/kg) reversed chemical and thermal hyperalgesia in diabetic rats. Administration of URB597 at a dose of 0.1 mg/kg did not alter pain-related behaviors in control and diabetic groups compared with those of the respective control groups. URB597 treatment did not affect body weight or plasma glucose level of treated animals compared with nontreated animals. This study shows that increasing endocannabinoid neurotransmission with URB597 displays efficacy in chemical and thermal models of diabetic hyperalgesia. It also suggests that URB597 is a promising tool for treatment of painful diabetic neuropathy.

Item Type: Article
Keywords: diabetes hyperalgesia neuropathy URB597 FAAH nociception rats formalin test tactile allodynia neuropathic pain gm1 ganglioside analgesia receptors anandamide models mice antinociception Pharmacology & Pharmacy Physiology
Page Range: pp. 432-439
Journal or Publication Title: Canadian Journal of Physiology and Pharmacology
Journal Index: ISI
Volume: 87
Number: 6
Identification Number: https://doi.org/10.1139/y09-026
ISSN: 0008-4212
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4891

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