Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Association of the CagA status of Helicobacter pylori and serum levels of interleukin (IL)-17 and IL-23 in duodenal ulcer patients

(2009) Association of the CagA status of Helicobacter pylori and serum levels of interleukin (IL)-17 and IL-23 in duodenal ulcer patients. Journal of Digestive Diseases. pp. 107-112. ISSN 1751-2972

[img] Text
5afc91627160ff19c925b316f533e918018b80b0517c047dfe7ef9d7ca125a63.pdf

Download (110kB)

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

It has been reported that the cytotoxin-associated gene A (cagA+) H. pylori strains induce severe gastric mucosal inflammation. The aim of this study was to investigate the association of the virulence factor CagA with IL-17 and IL-23 serum levels in duodenal ulcer (DU) patients and H. pylori-infected asymptomatic (AS) carriers. In total, 45 H. pylori-infected DU patients were enrolled to study: 23 tested positive for the anti-CagA antibody (anti-CagA+) and 22 tested negative for the anti-CagA antibody (anti-CagA-), 30 were AS carriers (15 were anti-CagA+ and 15 were anti-CagA-) and 15 were healthy uninfected participants (as a control group). The IL-17 and IL-23 serum levels of participants were measured by enzyme-linked immunosorbent assay method. The mean IL-17 levels in DU patients were significantly higher than those in AS and control groups (P < 0.001 and P < 0.0001 respectively). In the DU group, the mean IL-17 levels in participants testing positive for anti-CagA (10.84 +/- 5.79 pg/mL) were significantly higher than those observed in participants testing negative for anti-CagA (7.65 +/- 4.74 pg/mL; P < 0.05). The mean IL-23 levels in the DU and AS groups were significantly higher than in the control group (P < 0.02 and P < 0.03 respectively) but were not significantly different in participants testing positive and negative for anti-CagA. These results showed higher IL-17 and IL-23 serum levels in H. pylori-infected participants than in the control group. In the DU group the expression of IL-17 was influenced by the CagA factor.

Item Type: Article
Keywords: anti-CagA Helicobacter pylori interleukin-17 interleukin-23 peptic ulcer neutrophil-activating protein intestinal inflammation immune-responses immunoglobulin-g il-17 production th17 cells infection disease induction lineage Gastroenterology & Hepatology
Page Range: pp. 107-112
Journal or Publication Title: Journal of Digestive Diseases
Journal Index: ISI
Volume: 10
Number: 2
Identification Number: https://doi.org/10.1111/j.1751-2980.2009.00371.x
ISSN: 1751-2972
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4895

Actions (login required)

View Item View Item