Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Vitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats

(2009) Vitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats. Iranian Journal of Basic Medical Sciences. pp. 9-17. ISSN 2008-3866

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Abstract

Objective(s) Previous studies have demonstrated that pretreatment with alpha-tocotrienol (alpha-TCT) can reduce ischemic damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease stroke-dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present study, the neuroprotective effects of alpha-TCT and rosiglitazone (RGZ) at 3 hr after cerebral ischemia were investigated. Materials and Methods Stroke was induced by embolizing a preformed clot into the MCA. Rats were assigned to vehicle, alpha-TCT (1 or 10 mg/kg), RGZ and sham-operation. Results Compared to the control group, only RGZ decreased infarct volume (P<0.05), neurological deficits (P<0.05) and sensory impairments (P<0.01) but low and high doses of alpha-TCT did not show any significant neuroprotective effect. Conclusion Our data showed that alpha-TCT was not neuroprotective at 3 hr after the embolic model of stroke. Further studies should be undertaken to clarify the neuroprotective effects of alpha-TCT after stroke.

Item Type: Article
Keywords: Alpha-tocotrienol Cerebral ischemia Embolic model Neuroprotection Vitamin E transient focal ischemia receptor-gamma ligand model rosiglitazone infarction therapy combination occlusion window Research & Experimental Medicine Pharmacology & Pharmacy
Page Range: pp. 9-17
Journal or Publication Title: Iranian Journal of Basic Medical Sciences
Journal Index: ISI
Volume: 12
Number: 1
ISSN: 2008-3866
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4899

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