Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Helicobacter pylori infection and expression of DNA mismatch repair proteins

(2008) Helicobacter pylori infection and expression of DNA mismatch repair proteins. World Journal of Gastroenterology. pp. 6717-6721. ISSN 1007-9327

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Abstract

AIM: To determine the expression of DNA (MMR) proteins, including hMLH1 and hMSH2, in gastric epithelial cells in the patients with or without Helicobacter pylori(H pylori)-infected gastritis. METHODS: Fifty H pylori-positive patients and 50 H pylori-negative patients were enrolled in the study. During endoscopy of patients with non-ulcer dyspepsia, two antral and two corpus biopsies were taken for histological examination (Giemsa stain) and for immunohistochemical staining of hMLH1 and hMSH2. RESULTS: The percentage of epithelial cell nuclei that demonstrated positivity for hMLH1 staining was 84.14 +/- 7.32 in H pylori-negative patients, while it was 73.34 +/- 10.10 in H pylori-positive patients (P < 0.0001). No significant difference was seen between the two groups regarding the percentage of epithelial cell nuclei that demonstrated positivity for hMSH2 staining (81.16 +/- 8.32 in H pylori-negative versus 78.24 +/- 8.71 in H pylori-positive patients; P = 0.09). CONCLUSION: This study indicates that H pylori might promote development of gastric carcinoma at least in part through its ability to affect the DNA MMR system. (C) 2008 The WIG Press. All rights reserved.

Item Type: Article
Keywords: Helicobacter pylori DNA mismatch repair hMLH1, hMSH2 human gastric-mucosa microsatellite instability cell-proliferation colorectal-cancer epithelial-cells eradication defects mice Gastroenterology & Hepatology
Page Range: pp. 6717-6721
Journal or Publication Title: World Journal of Gastroenterology
Journal Index: ISI
Volume: 14
Number: 43
Identification Number: https://doi.org/10.3748/wjg.14.6717
ISSN: 1007-9327
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4905

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