Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Seroprevalence of anti-Helicobacter pylori and anti-CagA antibodies among healthy children according to age, sex, ABO blood groups and Rh status in south-east of Iran

(2007) Seroprevalence of anti-Helicobacter pylori and anti-CagA antibodies among healthy children according to age, sex, ABO blood groups and Rh status in south-east of Iran. Turkish Journal of Gastroenterology. pp. 165-171. ISSN 1300-4948

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Abstract

Background/aims: The aim of this study was to evaluate the seroprevalence of anti-Helicobacter pylori (H. pylori) and anticytotoxin associated antigen A (CagA) antibodies in healthy children and to investigate the relation. with age, sex, ABO blood groups and Rh status. Methods: Serum samples from 386 children (187 males, 199 females), aged 1-15 years, were tested for the presence of antibody to H. pylori and its virulence factor (CagA) by use of ELISA. ABO blood grouping was also done by hemagglutination test. Results: The overall seroprevalence of H. pylori infection was 46.6. The prevalence of anti-H. pylori antibody was significantly (p<0.05) higher in males (51.9) compared to females (41.7). The prevalence of anti-CagA antibody in infected children was 72.8. Although the prevalence of anti-CagA antibody was higher in males (78.4) compared to females (66.3), the difference was not statistically significant (p=0.07). In age subgroups of 1-5 years, 6-10 years and 11-15 years, the prevalence of anti-H. pylori was 37.6, 46.9 and 54.9 and in infected children, the prevalence and the mean titer of anti-CagA antibody were 63.8, 75.94 Uarb/ml; 75, 63.32 Uarb/ml and 79.45, 57.11 Uarb/ml; respectively. The seroprevalences of anti-H. pylori and anti-CagA (in infected children) were 53 and 77.3 in blood group A 50.5 and 64.7 in blood group B, 44.4 and 62.5 in blood group AB, 41.6 and 76.8 in blood group O, 45.9 and 73 in Rh(+) phenotype and 54.84 and 70.6 in Rh(-) phenotype, respectively. There was no significant difference in the prevalence of either antibody between ABO blood groups or Rh status groups. However, within blood group A, the prevalence of anti-H. pylori and anti-CagA was significantly higher in males compared to females (p<0.05). Conclusions: These results showed that almost half of the children acquire H. pylori infection. Anti-CagA antibody is also common in the children. The seroprevalences of anti-H. pylori and anti-CagA antibodies were higher in males and increased with age. However, the mean titer of anti-CagA antibodies decreased with increasing age. ABO blood groups may partly influence the prevalence of H. pylori infection, especially in male gender.

Item Type: Article
Keywords: Helicobacter pylori antigen A seroprevalence ABO blood groups children Iran sex high prevalence risk-factors infection epidemiology population adults Gastroenterology & Hepatology
Page Range: pp. 165-171
Journal or Publication Title: Turkish Journal of Gastroenterology
Journal Index: ISI
Volume: 18
Number: 3
ISSN: 1300-4948
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4921

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