Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Changes in neuromodulatory effect of adenosine A(1) receptors on piriform cortex field potentials in amygdala kindled rats

(2007) Changes in neuromodulatory effect of adenosine A(1) receptors on piriform cortex field potentials in amygdala kindled rats. European Journal of Pharmacology. pp. 60-67. ISSN 0014-2999

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Adenosine exerts its anticonvulsants effect through different brain regions including piriform cortex. In this study, the effect of amygdala kindled seizures on adenosine A, receptor-mediated neuromodulation in piriform cortex pyramidal neurons was tested at 24 h and I month after kindling. Animals were kindled by daily electrical stimulation of amygdala. Field potentials were recorded from layer 11 of piriform cortex pyramidal cells following stimulation of the lateral olfactory tract. Obtained results showed that N-6-cyclohexyladenosine (CHA), a selective adenosine A(1) receptor agonist (1, 10 and 100 mu M; i.c.v.), reduced Al slope and B1 amplitude of field potentials in both kindled and non-kindled (control) rats. However, its effects on kindled animals were more potent at 24 h, but not I month post-kindling. 8 cyclopenthyl-1,3-dimethylxanthine (CPT), a selective adenosine A, receptor antagonist (50 mu M, i.c.v.), had no significant effect on the field potential parameters. However, CPT (50 mu M, i.c.v.) pretreatment eliminated effects of CHA (10 mu M; i.c.v.) on the field potentials. These results indicate that activation of adenosine A, receptors has an inhibitory effect on the field potentials of piriform cortex pyramidal neurons and the efficiency of adenosine A(1) receptor neuromodulation in piriform cortex is increased at short-term (24 h) but return to normal at long-term (I month) after kindling implementation. (c) 2007 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: seizure adenosine receptor piriform cortex amygdala kindling temporal-lobe epilepsy pentylentetrazol-induced seizures synaptic-transmission electrical stimulation adenylate-cyclase up-regulation mouse-brain area ca1 hippocampus a1 Pharmacology & Pharmacy
Page Range: pp. 60-67
Journal or Publication Title: European Journal of Pharmacology
Journal Index: ISI
Volume: 565
Number: 1-3
Identification Number:
ISSN: 0014-2999
Depositing User: مهندس مهدی شریفی

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