Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

The effect of the anti-diabetic drug metformin on behavioral manifestations associated with ovariectomy in mice

(2019) The effect of the anti-diabetic drug metformin on behavioral manifestations associated with ovariectomy in mice. Neuroscience Letters. pp. 95-98. ISSN 1872-7972 (Electronic) 0304-3940 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/30321576

Abstract

The aim of this study was to evaluate the anti-diabetic drug metformin (Met) effects on the anxiety and cognitive impairment in ovariectomized mice. Thirty-two female adult mice were distributed into four groups: control, sham ovariectomy, ovariectomy + Met 7 mg/kg and ovariectomy + Met 15 mg/kg. The vaginal cytology was used to confirm the ovariectomy surgery. Anxiety was monitored using elevated plus maze test and cognitive function was assessed by novel object recognition task. Animal's brains were analyzed for the brain-derived neurotrophic factor (BDNF). Our results demonstrated that ovariectomy caused cognitive impairments and anxiety, as well as decreased BDNF levels. Moreover, administration of Met improves ovariectomy-related disorders such as cognitive impairments and anxiety, as well as increased BDNF levels. The results of the present study suggest that Met could be used as a novel therapeutic strategy for the treatment of ovariectomy-related conditions.

Item Type: Article
Keywords: Anxiety Cognition Metformin Ovariectomy
Page Range: pp. 95-98
Journal or Publication Title: Neuroscience Letters
Journal Index: Pubmed
Volume: 690
Identification Number: https://doi.org/10.1016/j.neulet.2018.10.024
ISSN: 1872-7972 (Electronic) 0304-3940 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4961

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