Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Treatment with troxerutin protects against cisplatin-induced kidney injury in mice

(2018) Treatment with troxerutin protects against cisplatin-induced kidney injury in mice. Acta chirurgica Belgica. pp. 1-7. ISSN 0001-5458 (Print) 0001-5458 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/29653502

Abstract

BACKGROUND: Cisplatin (CP) is a synthetic and anticancer drug, and one of the major side effects of CP is nephrotoxicity. This study was done to evaluate the renoprotective effects of troxerutin (Tro) in nephrotoxicity induced by CP in male mice. METHODS: In this experimental study, 28 male mice were divided randomly into four groups. Mice were treated with CP (20 mg/kg, i.p.) then Tro (75 and 150 mg/kg/day, po) was administered for three consecutive days. Blood samples were collected to determine serum creatinine (Cr) and blood urea nitrogen (BUN) levels. The kidney tissues were used for histological examination and biochemical assays. Malondialdehyde (MDA) level, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity were assessed in renal tissue. RESULTS: Results showed a significant increase in the Cr, BUN and MDA levels and a significant decrease in the renal SOD and GPx activity by CP administration. Treatment with Tro for three consecutive days attenuated these changes. Also, the renoprotective effect of the Tro was confirmed by the histological examination of the kidneys. CONCLUSIONS: Our results demonstrated that Tro has protective effects against CP-induced nephrotoxicity through improving the biochemical indices and the oxidative stress parameters.

Item Type: Article
Keywords: Nephrotoxicity antioxidant cisplatin mice troxerutin
Page Range: pp. 1-7
Journal or Publication Title: Acta chirurgica Belgica
Journal Index: Pubmed
Identification Number: https://doi.org/10.1080/00015458.2018.1455418
ISSN: 0001-5458 (Print) 0001-5458 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4981

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