Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Can tert-butylhydroquinone improve the healing of extracted tooth socket in rats?

(2017) Can tert-butylhydroquinone improve the healing of extracted tooth socket in rats? Dental research journal. pp. 8-12. ISSN 1735-3327 (Print) 1735-3327 (Linking)

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BACKGROUND: Tooth extraction causes an open wound in the soft and hard tissues. During the inflammatory phase of the healing process, a large amount of free radicals are produced and cause oxidative stress, which leads to tissue damage and delayed wound healing. Thus, in this study, we evaluated the effect of tert-butylhydroquinone (TBHQ), as an antioxidant, on the healing process of tooth sockets in rats. MATERIALS AND METHODS: To conduct this experimental study, male Wistar rats (n = 42) were divided into two groups. In each case, one upper second molar was extracted under general anesthesia. After the extraction, the tooth sockets of the experimental group were treated with a 0.02 TBHQ solution (0.1 ml) while the same volume of distilled water placed in the sockets of the control group. On days 3, 7, and 21 postoperatively, 7 rats from each group were euthanized, and histological slides were prepared from their tooth sockets. The prepared slides were examined histopathologically using a light microscope and compared using an independent two-sample t-test. The significance level was set at 0.05. RESULTS: In the experimental group, a statistically significant (P = 0.003) increase in granulation tissue was observed on day 3, in comparison to the control group. The extent of bony trabeculation was also significantly higher in the TBHQ-treated group than in the control group on day 21 (P < 0.001). CONCLUSION: Considering the limitations of an experimental study, it can be concluded that TBHQ may enhance the healing of the hard tissue in the tooth sockets.

Item Type: Article
Keywords: Antioxidants rats tooth extraction wound healing real or perceived, financial or non-financial in this article.
Page Range: pp. 8-12
Journal or Publication Title: Dental research journal
Journal Index: Pubmed
Volume: 14
Number: 1
ISSN: 1735-3327 (Print) 1735-3327 (Linking)
Depositing User: مهندس مهدی شریفی

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