Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

The expression of HoxB5 and SPC in neonatal rat lung after exposure to fluoxetine

(2016) The expression of HoxB5 and SPC in neonatal rat lung after exposure to fluoxetine. Drug design, development and therapy. pp. 3323-3329. ISSN 1177-8881 (Electronic) 1177-8881 (Linking)

[img] Text

Download (2MB)

Official URL:


OBJECTIVE: Approximately 10 of pregnant women suffer from pregnancy-associated depression. Fluoxetine, as a selective serotonin reuptake inhibitor, is being employed as a therapy for depressive disorders. The present study aimed to determine the effects of fluoxetine on neonatal lung development. METHODS: Thirty pregnant Wistar rats (weighing 200-250 g) were treated daily with 7 mg/kg fluoxetine from gestation day 0 to gestation day 21, via gavage. The control group received a similar volume of distilled water only. Following delivery, the newborns and their lungs were immediately weighed in both of the groups. The right lung was fixed for histological assessments while the left lung was used for evaluation of the expression of SPC and HoxB5 by the real-time polymerase chain reaction method. RESULTS: Results have indicated that even though the body weight and the number of neonatal rats in both groups were the same, the lung weight of neonates exposed to fluoxetine was significantly different compared to the control group (P<0.05). Expression of both genes was increased, nonetheless, only elevation of HoxB5 was significant (P<0.05). Histological studies demonstrated that lung tissue in the fluoxetine treatment group morphologically appears to be similar to the pseudoglandular phase, whereas the control group lungs experienced more development. CONCLUSION: According to the upregulated expression of HoxB5 concerning histological findings, results of the present study showed that fluoxetine can influence lung growth and may in turn lead to delay in lung development. So establishment of studies to identify the effects of antidepressant drugs during pregnancy is deserved.

Item Type: Article
Keywords: Animals Animals, Newborn Antidepressive Agents/*pharmacology Female Fluoxetine/*pharmacology Lung/*physiology Pregnancy Rats Rats, Wistar Real-Time Polymerase Chain Reaction/methods Serotonin Uptake Inhibitors/*pharmacology *HoxB5 *spc *fluoxetine *lung *rat
Page Range: pp. 3323-3329
Journal or Publication Title: Drug design, development and therapy
Journal Index: Pubmed
Volume: 10
Identification Number:
ISSN: 1177-8881 (Electronic) 1177-8881 (Linking)
Depositing User: مهندس مهدی شریفی

Actions (login required)

View Item View Item