Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Association of S100 calcium-binding protein A12, receptor for advanced glycation endproducts, and nuclear factor-κB expression with inflammation in pulp tissues from tooth caries

(2018) Association of S100 calcium-binding protein A12, receptor for advanced glycation endproducts, and nuclear factor-κB expression with inflammation in pulp tissues from tooth caries. Journal of Investigative and Clinical Dentistry. ISSN 20411626 (ISSN)

[img] Text
khorasani2017.pdf

Download (393kB)

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

AIM: S100 calcium-binding protein A1 (S100A12) is a pro-inflammatory molecule which is secreted during inflammation and induces chemotaxis and the production of pro-inflammatory cytokines via interaction with receptor for advanced glycation endproducts (RAGE) and subsequent, activation of nuclear factor-κB (NF-κB). The present study was designed to determine the expression levels of S100A12, RAGE, and NF-κB in the inflamed pulp of carried teeth. METHODS: In the present study, mRNA from 50 inflamed pulp and 50 healthy pulp were used for expression studies using real-time polymerase chain reaction. The expression levels of S100A12, RAGE, and NF-κB were compared between inflamed and healthy tissues. RESULTS: The results revealed that the expression of S100A12, but not of RAGE or NF-κB, was significantly decreased in inflamed pulp when compared to healthy pulp. mRNA levels of RAGE were also increased in the inflamed pulp taken from men when compared with women. CONCLUSION: The results suggest that S100A12 does not participate in the induction of inflammation in dental pulp. However, RAGE can participate in the inflammation in the pulp of males. © 2017 John Wiley & Sons Australia, Ltd.

Item Type: Article
Keywords: nuclear factor-κB pulp receptor for advanced glycation endproducts S100 calcium-binding protein A1 tooth calgranulin C cytokine immunoglobulin enhancer binding protein messenger RNA mitogen activated protein kinase MOK protein, human S100A12 protein, human tumor antigen biosynthesis cross-sectional study dental caries female gene expression genetics human male metabolism pathology periodontitis sex factor tooth pulp disease young adult Antigens, Neoplasm Cross-Sectional Studies Cytokines Dental Pulp Diseases Humans Mitogen-Activated Protein Kinases NF-kappa B RNA, Messenger S100A12 Protein Sex Factors
Journal or Publication Title: Journal of Investigative and Clinical Dentistry
Journal Index: Scopus
Volume: 9
Number: 1
Identification Number: https://doi.org/10.1111/jicd.12290
ISSN: 20411626 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/5166

Actions (login required)

View Item View Item