Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

TGF-β in Toxoplasmosis: Friend or foe?

(2016) TGF-β in Toxoplasmosis: Friend or foe? Cytokine. pp. 29-35. ISSN 10434666 (ISSN)

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Abstract

Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan causing several forms of toxoplasmosis in humans. The main mechanisms that allow the development of the prolonged forms of the disease and its subsequent pathology are yet to be clarified. However, many researchers have hypothesized that immunological and genetic parameters may play crucial roles in the etiology of the disease. Transforming growth factor beta (TGF-β) is a cytokine with a dual role in the regulation of immune responses including those against parasites. However, the relationship between TGF-β and immune responses against Tgondii are not fully understood. The important roles played by TGF-β in the development of Th17 and T regulatory lymphocytes, mucosal immunity and regulation of immune responses have been documented and this provides insights into TGF-β function during parasitic infections such as toxoplasmosis. Therefore, the aim of this review is to collate the current information regarding the status and association of TGF-β with T. gondii infection. © 2016 Elsevier Ltd

Item Type: Article
Keywords: T regulatory lymphocytes TGF-β Th17 Toxoplasma gondii transforming growth factor beta cytokine gamma interferon adaptive immunity cytokine response human immune evasion immunoregulation inflammation innate immunity mucosal immunity nonhuman parasite immunity priority journal regulatory T lymphocyte Review Th17 cell toxoplasmosis animal animal toxoplasmosis immunology mouse physiology Toxoplasma Animals Cytokines Humans Immunity, Innate Interferon-gamma Mice T-Lymphocytes, Regulatory Th17 Cells Toxoplasmosis, Animal
Page Range: pp. 29-35
Journal or Publication Title: Cytokine
Journal Index: Scopus
Volume: 86
Identification Number: https://doi.org/10.1016/j.cyto.2016.07.002
ISSN: 10434666 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/5214

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