Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Vitex agnus castus extract improves learning and memory and increases the transcription of estrogen receptor α in hippocampus of ovariectomized rats

(2015) Vitex agnus castus extract improves learning and memory and increases the transcription of estrogen receptor α in hippocampus of ovariectomized rats. Basic and Clinical Neuroscience. pp. 185-192. ISSN 2008126X (ISSN)

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Abstract

Introduction: Lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. Although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormonedependent cancers. Phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related cognitive decline. Methods: 24 female Wistar rats weighing 180-220g were used in this study. The animals were ovariectomized and randomly divided into four groups including, control and two groups which received 8 and 80mg/kg Vitex agnus castus (VAC) ethanolic extract orally. The last groups were treated with 40μg/kg of estradiol valerat. Step-through passive avoidance (STPA) test was used for the evaluation of learning and memory. The hippocampal estrogen receptor α (ERα) expression was measured using Real-Time PCR. Results: The results demonstrated that VAC extract or estradiol had better performance on stepthrough passive avoidance test than control group (all P<0.05). Moreover, administration of either estradiol or VAC extract increased the hippocampal mRNA level of ERα and prevented the decrease in uterine weight of ovariectomized rats. Discussion: Based on our data, VAC extract improves learning and memory in ovariectomized rats. The positive effect of VAC extract on learning and memory is possibly associated with an increase in ERα gene expression in the hippocampal formation.

Item Type: Article
Keywords: Estrogen receptor alpha Memory Ovariectomy Vitex agnus-castus alcohol estradiol valerate messenger RNA Vitex agnus castus extract animal experiment animal model animal tissue Article brain development controlled study drug dose comparison drug mechanism female gene expression genetic association hippocampus learning locomotion morning dosage nonhuman protein expression rat real time polymerase chain reaction step-through passive avoidance test task performance transcription regulation treatment duration uterus weight
Page Range: pp. 185-192
Journal or Publication Title: Basic and Clinical Neuroscience
Journal Index: Scopus
Volume: 6
Number: 3
ISSN: 2008126X (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/5256

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