Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Association of a polymorphism within intron 8 but not exon 9 of the vitamin D receptor in patients with multiple sclerosis of southeastern Iranian ethnicity

(2013) Association of a polymorphism within intron 8 but not exon 9 of the vitamin D receptor in patients with multiple sclerosis of southeastern Iranian ethnicity. Laboratory Medicine. pp. 215-219. ISSN 00075027 (ISSN)

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Abstract

Objective: To investigate the association between multiple sclerosis (MS) and polymorphisms in intron 8 and exon 9 of the vitamin D receptor (VDR) gene. Methods: Blood samples were collected from 100 patients with MS and 100 healthy control individuals in ethylenediaminetetraacetic acid (EDTA) tubes. DNA was extracted and analyzed via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for polymorphisms within the VDR. Demographic data were also collected via a questionnaire designed specifically for this study. Results: Our results showed a significant difference between the A/A genotype and between the A and a alleles of intron 8 of VDR; however, no differences were observed in the other studied alleles. Conclusion: VDR and its functional polymorphisms may be associated with MS.

Item Type: Article
Keywords: Multiple sclerosis Polymorphism Vitamin D receptor colecalciferol receptor edetic acid restriction endonuclease adult amino acid sequence article blood sampling controlled study demography disease predisposition DNA extraction ethnicity exon female genetic association genetic polymorphism genotype human intron Iran major clinical study male polymerase chain reaction questionnaire restriction fragment length polymorphism
Page Range: pp. 215-219
Journal or Publication Title: Laboratory Medicine
Journal Index: Scopus
Volume: 44
Number: 3
Identification Number: https://doi.org/10.1309/LM8GLJHWING18CLB
ISSN: 00075027 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/5292

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