Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

No association between CCR5-Δ32 mutation and multiple sclerosis in patients of Southeastern Iran

(2010) No association between CCR5-Δ32 mutation and multiple sclerosis in patients of Southeastern Iran. Laboratory Medicine. pp. 31-33. ISSN 00075027 (ISSN)

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Abstract

Background: Multiple sclerosis (MS) is considered a complicated autoimmune disorder. Evidence is in favor of involvement of chemokines and their receptors in autoimmune diseases. Hence, this project aimed to analyze the known CCR5-Δ32 mutation in MS patients. Methods: In this experimental study, blood samples were collected from 100 MS patients and 300 healthy controls in EDTA pre-coated tubes. DNA was extracted and DNA samples were analyzed for CCR5-Δ32 mutation by Gap-PCR in patients and controls. Demographic data were also collected by questionnaire. Results: Our findings showed that none of the MS patients displayed CCR5-Δ32 mutation, while 2 healthy controls showed the heterozigotic form of this mutation Conclusions: Several studies analyzed the relation of this mutation with autoimmune diseases. Some studies failed, but some succeeded in finding an association between this mutation and autoimmune diseases. Based on the results of our study, it could be concluded that this mutation does not play a role in the etiology and pathogenesis of MS.

Item Type: Article
Keywords: chemokine receptor CCR5 adult article autoimmune disease blood sampling controlled study DNA extraction female gene mutation genetic association heterozygosity human Iran major clinical study male multiple sclerosis pathogenesis
Page Range: pp. 31-33
Journal or Publication Title: Laboratory Medicine
Journal Index: Scopus
Volume: 41
Number: 1
Identification Number: https://doi.org/10.1309/LM9TU9ID1CGZVLXL
ISSN: 00075027 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/5366

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