Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

The study of the serum level of IL-4, TGF-β, IFN-γ, and IL-6 in overweight patients with and without diabetes mellitus and hypertension

(2019) The study of the serum level of IL-4, TGF-β, IFN-γ, and IL-6 in overweight patients with and without diabetes mellitus and hypertension. Journal of Cellular Biochemistry. pp. 4147-4157.

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Abstract

Background: Obesity increases the risk of diabetes mellitus (DM) and hypertension. We aimed to analyze the serum levels of cytokines that have relevance to the pathologies including, interleukin-4 (IL-4), transforming growth factor-β (TGF-β), interferon-γ (IFN-γ), and IL-6 cytokines of overweight men with DM and/or hypertension. Methods: The study collected serum from 164 men. The sample population contained, 54 overweight men without DM or hypertension (control CTL group), 36 men with both DM and hypertension (DH group), 20 men with DM but no hypertension (D group), and 54 had hypertension without DM (H). Results: The main results showed that the concentration of IFN-γ in the DH group was significantly higher than the D, H, and CTL groups, IL-6 in DH and D groups was significantly lower than the CTL group. The serum level of TGF-β and IL-4 cytokines did not show any significant differences across the four groups. Serum levels of IL-6 were also significantly lower in untreated patients in D group than controls and in DH when compared with H groups. Conclusion: In conclusion, it appears that the proinflammatory and anti-inflammatory cytokines either play a significant role in the pathogenesis of hypertension and DM or serve as markers for these pathologies. Accordingly, increased serum levels of IFN-γ may participate in the pathogenesis of hypertension in the diabetic patients and decreased IL-6 is associated with type 2 DM. © 2018 Wiley Periodicals, Inc.

Item Type: Article
Keywords: cytokine diabetes mellitus hypertension immune system obesity gamma interferon interleukin 4 interleukin 6 transforming growth factor beta adult Article blood sampling human major clinical study male obese patient priority journal protein blood level protein expression protein structure
Subjects: QW Microbiology and Immunology > QW 501-949 Immunology
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Immunology Department
Research Vice-Chancellor Department > Immunology of Infectious Diseases Research Center
Page Range: pp. 4147-4157
Journal or Publication Title: Journal of Cellular Biochemistry
Journal Index: Pubmed
Volume: 120
Number: 3
Publisher: Wiley Periodicals, Inc.
Identification Number: https://doi.org/10.1002/jcb.27700
Depositing User: خانم مهتاب اکبری
URI: http://eprints.rums.ac.ir/id/eprint/6585

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