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Rafsanjan University of Medical Sciences

An efficient induction protocol for deriving mature oligodendrocytes from human dental stem cells

(2019) An efficient induction protocol for deriving mature oligodendrocytes from human dental stem cells. Bratislava Medical Journal-Bratislavske Lekarske Listy. pp. 86-88. ISSN 0006-9248

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Abstract

INTRODUCTION: This study examined the process of deriving mature oligodendrocytes from human dental pulp stem cells (hDPSCs) via addition of cerebrospinal fluid (CSF). METHODS: The hDPSCs were cultured in the presence of retinoic acid and CSF. The oligodendrocytes were confirmed using immunocytochemistry for specific glial markers, namely Olig2 and MBP markers. RESULTS: The differentiated oligodendrocytes were immunopositive for Olig2 and MBP markers at the end of induction phase. CONCLUSION: It is concluded that this study indicated the glial differentiation of hDPSCs in the presence of CSF and appropriate inducers, which is a usable therapeutic technique in neuroregenerative medicine (Fig. 3, Ref. 24).

Item Type: Article
Keywords: human dental pulp stem cells oligodendrocyte cerebrospinal fluid retinoic acid in-vitro differentiation neuron-like cells cerebrospinal-fluid pulp
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 100-133 Biochemistry of the Human Body
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Clinical Biochemistry
Page Range: pp. 86-88
Journal or Publication Title: Bratislava Medical Journal-Bratislavske Lekarske Listy
Journal Index: ISI, Pubmed, Scopus
Volume: 120
Number: 1
Publisher: COMENIUS UNIV, SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
Identification Number: https://doi.org/10.4149/bll_2019_013
ISSN: 0006-9248
Depositing User: خانم مهتاب اکبری
URI: http://eprints.rums.ac.ir/id/eprint/6589

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