Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Neuroprotective effects of Ellagic acid against acrylamide-induced neurotoxicity in rats

(2019) Neuroprotective effects of Ellagic acid against acrylamide-induced neurotoxicity in rats. Neurol Res. pp. 1-10. ISSN 01616412

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Acrylamide (ACR) is an environmental contaminant and a well-known neurotoxin. Ellagic acid (EA), a natural plant polyphenol, has shown a variety of beneficial effects. The present study was designed to explore whether EA could attenuate ACR-induced neurotoxicity in rats and to explore the underlying mechanisms. Animals were divided into five groups. Group 1 was treated with normal saline (2 mL/kg) for 30 days. Group 2 was treated with ACR (20 mg/kg, orally) for 30 days. Groups 3 and 4 were treated with ACR and EA (10 and 30 mg/kg, orally) for 30 days. Group 5 was treated with EA (30 mg/kg, orally) for 30 days. Open field, rotarod and passive avoidance test were conducted to evaluate behavioral changes, respectively. The brain cortex was used for histological examination. Different oxidative parameters and inflammatory biomarkers were assessed in the brain cortex. ACR-administered rats showed a considerable impairment in exploratory behavior, motor performance as well as cognition. Our data also showed that ACR administration significantly increases malondialdehyde, nitric oxide, interleukin-1beta and tumor necrosis factor-alpha levels. Moreover, it decreases brain glutathione level, superoxide dismutase, glutathione peroxidase, catalase activity. Co-administration of EA (especially 30 mg/kg, p.o.) prevented these changes; however, it did not affect the glutathione peroxidase activity. These results were supported by histopathological observations of the brain. Our results suggest that EA can be useful for protecting brain tissue against ACR-induced neurotoxicity through ameliorative effects on inflammatory indices and oxidative stress parameters.

Item Type: Article
Keywords: Acrylamide; Ellagic acid; neurotoxicity; rat
Subjects: QT Physiology > QT104-172 Human Physiology
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Physiology
Research Vice-Chancellor Department > Physiology-Pharmacology Research Center
Page Range: pp. 1-10
Journal or Publication Title: Neurol Res
Journal Index: ISI, Pubmed, Scopus
Publisher: Taylor and Francis Ltd.
Identification Number:
ISSN: 01616412
Depositing User: خانم مهتاب اکبری

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